| 2021-10-20 20:00:00October 20, 2021 | Madrid  | 20:00:008:00 PM | BYE | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Napoli | 20:00:008:00 PM | PSG | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | West Ham | 20:00:008:00 PM |  Villarreal | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Dortmund | 20:00:008:00 PM | Chelsea | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Aston Villa | 20:00:008:00 PM | Santa Clara | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Atlanta | 20:00:008:00 PM | Marseille | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Wolfsburg | 20:00:008:00 PM | Milan | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Man City | 20:00:008:00 PM | Bayern | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Arsenal | 20:00:008:00 PM | Lyon | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Betis  | 20:00:008:00 PM | Venezia | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Galatasaray | 20:00:008:00 PM | Spurs | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Sociedad  | 20:00:008:00 PM | Watford | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Inter | 20:00:008:00 PM | River Plate | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Galaxy | 20:00:008:00 PM | Monaco | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Norwich  | 20:00:008:00 PM | Sporting | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Liverpool | 20:00:008:00 PM | BYE | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Swansea  | 20:00:008:00 PM | BYE | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Brighton | 20:00:008:00 PM | Kaizer Chiefs | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Leipzig | 20:00:008:00 PM | Leeds | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Porto  | 20:00:008:00 PM | Ajax | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | LAFC | 20:00:008:00 PM | Leverkusen | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Celtic | 20:00:008:00 PM | Boca | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Portsmouth | 20:00:008:00 PM | Rangers | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Everton | 20:00:008:00 PM | Toronto | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Cope | 20:00:008:00 PM | Palace | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Man United | 20:00:008:00 PM | Dallas | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | NYCFC | 20:00:008:00 PM | Benfica | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Leicester | 20:00:008:00 PM | AIK Fotboll | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Atletico | 20:00:008:00 PM |  Dynamo | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Frankfurt | 20:00:008:00 PM | Sevilla | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Barcelona | 20:00:008:00 PM | Wolves | League One, League Two, Super League | Season 18 | N/A | - |
| 2021-10-20 20:00:00October 20, 2021 | Orlando | 20:00:008:00 PM | BYE | League One, League Two, Super League | Season 18 | N/A | - |
